﴿ لَعَلَّكَ بَٰخِعٌۭ نَّفْسَكَ أَلَّا يَكُونُوا۟ مُؤْمِنِينَ ﴾

“Wouldst thou, perhaps, torment thyself to death [with grief] because they [who live around thee] refuse to believe [in it]?”

Perhaps O Muhammad (s) you might kill yourself out of distress for the reason that they namely the people of Mecca will not become believers la‘alla here expresses sympathy in other words what is meant is ‘have pity on it your self by alleviating the burden of this distress’.