﴿ يَٰحَسْرَةً عَلَى ٱلْعِبَادِ ۚ مَا يَأْتِيهِم مِّن رَّسُولٍ إِلَّا كَانُوا۟ بِهِۦ يَسْتَهْزِءُونَ ﴾

“OH, THE REGRETS that [most] human beings will have to bear! Never has an apostle come to them without their deriding him!”

Ah the anguish for servants such as these and their like from among those who denied the messengers and were destroyed this word hasra denotes ‘extreme agony’; the vocative here is being used metaphorically in other words ‘It is time for you O anguish so come now!’. Never did a messenger come to them but that they mocked him this statement is given as an explanation of the cause thereof of the ‘agony’ since it the statement entails their mockery which itself results in their being destroyed and which in turn is the cause of the ‘anguish’.